Search results for "lung edema"

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Pre-treatment with mesenchymal stem cells reduces ventilator-induced lung injury

2012

ckground information: Bone marrow-derived mesenchymal stem cells (MSCs) reduce acute lung injury in animals challenged by bleomycin or bacterial lipopolysaccaride. It is not known, however, whether MSCs protect from ventilator- induced lung injury (VILI). Question of the study: Whether MSCs have a potential role in preventing or modulating VILI in healthy rats subjected to high-volume ventilation. Materials and methods: 24 Sprague-Dawley rats (250-300 g) were subjected to high- volume mechanical ventilation (25 ml/kg). MSCs (5x106) were intravenously or intratracheally administered (N=8 each) 30 min before starting over-ventilation and 8 rats were MSC-untreated. Spontaneously breathing anes…

MalePulmonary and Respiratory MedicinePathologymedicine.medical_specialtyAdministration TopicalVentilator-Induced Lung Injurymedicine.medical_treatmentVascular Cell Adhesion Molecule-1Pulmonary EdemaSettore MED/10 - Malattie Dell'Apparato RespiratorioLung injuryMesenchymal Stem Cell TransplantationBleomycinRats Sprague-Dawley03 medical and health scienceschemistry.chemical_compound0302 clinical medicineAcute lung injury cell therapy injurious ventilation lung edema lung inflammation mechanical ventilationAnimalsMedicineMacrophageCell adhesionLung030304 developmental biologyMechanical ventilation0303 health sciencesmedicine.diagnostic_testbusiness.industryMesenchymal stem cellrespiratory systemRatsrespiratory tract diseasesDisease Models AnimalBronchoalveolar lavage030228 respiratory systemchemistryBreathingAdministration IntravenousInflammation MediatorsbusinessBronchoalveolar Lavage FluidEuropean Respiratory Journal

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Noninvasive Ventilation in Critically Ill Patients

2015

Since its first application in the late 1980s, noninvasive ventilation (NIV) has been the first-line intervention for certain forms of acute respiratory failure. NIV may be delivered through the patient's mouth, nose, or both using noninvasive intermittent positive pressure ventilation or continuous positive airway pressure. When applied appropriately, NIV may reduce morbidity and mortality and may avert iatrogenic complications and infections associated with invasive mechanical ventilation. This article provides physicians and respiratory therapists with a comprehensive, practical guideline for using NIV in critical care. © 2015 Elsevier Inc.

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